NFIN - The Nothobranchius furzeri Information Network

Nothobranchius furzeri


The aim of this website is to provide information on the short-lived killifish Nothobranchius furzeri and foster a group of interest that employs this species as a vertebrate model for developmental and aging research.

Nothobranchius furzeri has several characteristics that make it a particularly attractive model to study biomedical aspects of aging:


NFINgb - The N. furzeri Genome Browser

At FLI, we sequenced and annotated the N. furzeri genome to facilitate genome-wide analyses and the identification of molecular factors determining the N. furzeri life-span. We present a high-quality draft sequence of the inbred GRZ strain. The assembly comprises 1.24Gb (N50: 57Mb), of which we assigned 87% (1.08Gb, N50: 64Mb) to 19 putative chromosomes. At NFINgb, you can explore the annotated N. furzeri genome.

To analyze genetic variation at genome-wide scale, at FLI we sequenced the genomes of further specimens of short- and longer-lived N. furzeri strains (GRZ, MZM-0403, MZM-0410 and MZZW-0701). NFINgb provides access to these variation data.

Reference: Reichwald, Petzold, Koch, Downie, Hartmann, ..., Cellerino, Englert, Platzer: Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish. Cell 2015, 163:1527-1538 (see abstract).


Stanford Killifish Genome Browser

Stanford GB
At Stanford, we de-novo assembled, annotated and analyzed the genome of the GRZ inbred strain to ~80x coverage to understand the evolution and genetic architecture of longevity in this species. We also sequenced additional strains of this fish to identify SNPs and variants. Here, you can explore the draft killifish genome, browse genetic variation, histone marks and other genomic features.

Reference: Valenzano, Benayoun, Singh, ..., Brunet: The African Turquoise Killifish Genome Provides Insights into Evolution and Genetic Architecture of Lifespan. Cell 2015, 163:1539-1554 (see abstract).


NFINtb - The N. furzeri Transcriptome Browser

At FLI, we sequenced normalized and non-normalized cDNA libraries using Sanger, Roche and Illumina technologies. We identified and annotated 19,875 protein-coding genes. Of these, 71% are represented by at least one transcript contig with a complete coding sequence. The NFINtb provides these data, plus comparisons to medaka, stickleback, tetraodon and zebrafish. It serves as a reference for expression analyses, e.g. young vs. old fish, and studying molecular, biochemical and evolutionary aspects of aging in N. furzeri.

Reference: Petzold et al. BMC Genomics 2013, 14:185 (//


last update of this page: February 28, 2023

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